• Modified Oligos

OverviewLiterature/SupportOrdering Information

Bioneer provides an extensive range of 5', internal and 3' modifications for your specialised applications. With the advent of technologies such as real-time detection and quantification as well as mass-scale genotyping projects, more scientists are requiring the access to modified Oligos. Most common Oligo modifications are available. Our fluorogenic oligos for qPCR are unsurpassed in quality and well-priced for value. In addition to the modifications listed included our ordering information, we may be able to accommodate other custom oligo modifications to meet your needs. Please enquire.

Features and Benefits

Free Bio-RP purification: Near HPLC purity at a standard Oligo price
Broad range of modifications available: If you don’t see it, just ask, we can probably do it
Competitive pricing: Great value for your research dollar

Manual

• Treatment for thiol modified oligonucleotides

• Anneal complementary pairs of oligonucleotides

MSDS

• Oligos

Brochure

• Oligonucleotides 2010 Brochure

FAQ

• Oligo FAQ

Quality Assurance

Bioneer is the holder of Quality Management System Certificates for the following standards.

• ISO 9001:2008 - certificate

• EN ISO 13485:2003 / AC:2009 - certificate

• EC Directive 98/79/EC - certificate

Modification Oligos Price

3' Modification

Modification	Price/Modification ($)					Working Day
Modification	0.05 umole	0.2 umole	1 umole	10 umole	15 umole	Working Day
DIG	82.50	92.50	142.50	712.50	NA	4
C6 Amine	15.00	30.00	47.00	235.00	NA	4
Phosphate	22.00	30.00	45.00	240.00	NA	4
Biotin	54.00	60.00	100.00	520.00	NA	4
C3 spacer	36.00	45.00	66.00	280.00	NA	4
C6 spacer	36.00	45.00	66.00	280.00	NA	4
C12 spacer	36.00	45.00	66.00	280.00	NA	4
C18 atom spacer	45.00	55.00	80.00	325.00	NA	4
dS spacer	47.00	55.00	80.00	320.00	NA	4
FAM	50.00	60.00	110.00	670.00	NA	4
TAMRA	77.00	96.00	137.00	750.00	NA	4
Thiol	70.00	90.00	130.00	690.00	NA	4
Texas Red	165.00	185.00	285.00	1425.00	NA	4
JOE	165.00	185.00	285.00	1425.00	NA	4
ROX	140.00	150.00	250.00	1250.00	NA	4
Cy5	95.00	115.00	175.00	1050.00	NA	4
Cy3	95.00	115.00	175.00	1050.00	NA	4
Dabcyl	80.00	100.00	200.00	1050.00	NA	4
BHQ1	80.00	100.00	200.00	1050.00	NA	4
BHQ2	80.00	100.00	200.00	1050.00	NA	4
Cholesteryl	80.00	100.00	240.00	1200.00	NA	4
3'-Inverted dT	38.00	50.00	80.00	380.00	NA	4
3'-Inverted dA	38.00	50.00	80.00	380.00	NA	4
3'-Inverted dC	38.00	50.00	80.00	380.00	NA	4
3'-Inverted dG	38.00	50.00	80.00	380.00	NA	4
Ara-dC	80.00	100.00	310.00	Under 3 (set-up charge $200.00)		4
5-F-dU	90.00	110.00	350.00	Under 3 (set-up charge $250.00)		4
2',3'-ddC	80.00	100.00	310.00	Under 3 (set-up charge $200.00)
AlexaFluor 488	180.00	200.00	350.00	1,750.00		4
AlexaFluor 532	250.00	275.00	430.00	2,150.00		4
AlexaFluor 546	250.00	275.00	430.00	2,150.00		4
AlexaFluor 594	288.00	325.00	520.00	2,600.00		4
AlexaFluor 647	180.00	200.00	350.00	1,750.00		4
AlexaFluor 660	288.00	325.00	520.00	2,600.00		4
AlexaFluor 750	288.00	325.00	520.00	2,600.00		4
N6-methyl-2'-deoxyadenosine	120.00	150.00	220.00	Under 3 (set-up charge $150.00)		4
DNP (2,4-dinitrophenyl)-TEG	125.00	175.00	275.00	Under 3 (set-up charge $150.00)		4
Cy3.5	180.00	250.00	380.00	1,050.00		4
Cy5.5	180.00	250.00	380.00	1,050.00		4
Puromycine	80.00	100.00	200.00	1,050.00		4
Yakima Yellow	120.00	150.00	220.00	Inquire		4
3'-dA	250.00	275.00	350.00			4
3'-dC	250.00	275.00	350.00			4
3'-dG	250.00	275.00	350.00			4
3'-dT	250.00	275.00	350.00			4
5-Nitroindole	125.00	175.00	250.00			4
2'-F-rA	65.00	80.00	115.00	Under 3 (set-up charge $150.00)		4
2'-F-rC	65.00	80.00	115.00	Under 3 (set-up charge $150.00)		4
2'-F-rG	65.00	80.00	115.00	Under 3 (set-up charge $150.00)		4
2'-F-rU	65.00	80.00	115.00	Under 3 (set-up charge $150.00)		4
Maleimide	50.00	65.00	95.00	Under 3 (set-up charge $150.00)		4
2-Aminopurine	75.00	90.00	125.00	Under 3 (set-up charge $150.00)		4
2,6-Diaminopurine	75.00	90.00	125.00	Under 3 (set-up charge $150.00)		4
Dithiol	150.00	175.00	275.00	1,500.00		4
EDTA-C2-dT	120.00	150.00	275.00	Under 3 (set-up charge $150.00)		4
Thymidine Glycol	150.00	175.00	275.00	Under 3 (set-up charge $150.00)		4
Zebularine	65.00	80.00	115.00	Under 3 (set-up charge $150.00)		4
3' Methylene Blue	150.00	175.00	275.00	Under 3 (set-up charge $250.00)		4
3' AMCA (amino-methyl-coumarin-acetate)	125.00	175.00	275.00	Under 3 (set-up charge $175.00)		4
3' Deoxypurine (2'-DeoxyNebu larine)	75.00	90.00	125.00	Under 3 (set-up charge $250.00)		4
3' PEG-2000	Inquire	Inquire	Inquire	Inquire	NA	4
3' Azide	150.00	175.00	275.00	1,500.00	NA	4
3' Acrylamide (acrydite)	90.00	110.00	350.00	1,500.00	NA	4
O₆-Methyl 2'-dG	75.00	90.00	125.00	375.00	NA
O₄-Methyl-dT	75.00	90.00	125.00	375.00	NA
dT-Alkyne	225.00	250.00	350.00	1,750.00	NA
Rhodamine 6G	180.00	250.00	380.00	1,050.00	NA
Epoch Eclips Quencher	225.00	250.00	350.00	1,750.00	NA
EBQ	112.00	135.00	350.00	594.00		4
Pyrene-dU	150.00	175.00	275.00	650.00
Perylene-dU	150.00	175.00	275.00	650.00	750.00
C8-Alkyne-dT	150.00	175.00	275.00	650.00
C8-Alkyne-dC	150.00	175.00	275.00	650.00
Desthiobiotin TEG	150.00	175.00	275.00	750.00
N3-Methyl dC	150.00	175.00	275.00	650.00
N4-Ethyl dC	150.00	175.00	275.00	650.00
Marina blue	125.00	175.00	250.00	1,250.00	NA
Azobenzene	125.00	175.00	250.00	1,250.00	NA

5' Modification

Modification	Price/Modification ($)					Working Day
Modification	0.05 umole	0.2 umole	1 umole	10 umole	15 umole	Working Day
DIG	82.50	92.50	142.50	712.50	NA	4
C6 Amine	10.00	25.00	40.00	190.00	NA	4
Phosphate	10.00	25.00	40.00	180.00	NA	4
Biotin	38.00	48.00	95.00	380.00	NA	4
Thiol	70.00	90.00	130.00	690.00	NA	4
C3 spacer	30.00	40.00	65.00	280.00	NA	4
C6 spacer	30.00	40.00	65.00	280.00	NA	4
C12 spacer	30.00	40.00	65.00	280.00	NA	4
18 atom spacer	47.00	55.00	80.00	320.00	NA	4
dS spacer	47.00	55.00	80.00	320.00	NA	4
FAM	56.00	67.00	142.00	565.00	NA	4
TAMRA	140.00	150.00	250.00	975.00	NA	4
HEX	55.00	66.00	138.00	600.00	NA	4
TET	55.00	66.00	138.00	600.00	NA	4
Texas Red	165.00	185.00	285.00	1425.00	NA	4
JOE	165.00	185.00	285.00	1425.00	NA	4
ROX	140.00	150.00	250.00	1250.00	NA	4
Cy5	80.00	100.00	200.00	1050.00	NA	4
Cy3	80.00	100.00	200.00	1050.00	NA	4
IRD700	80.00	100.00	200.00	1050.00	NA	4
IRD800	80.00	100.00	200.00	1050.00	NA	4
C2 Aldehyde	145.00	155.00	240.00	750.00	NA	4
Cy5.5	80.00	100.00	200.00	1050.00	NA	4
Cholesteryl	80.00	100.00	240.00	1200.00	NA	4
Dabcyl	145.00	175.00	240.00	1200.00	NA	4
Ara-dC	80.00	100.00	310.00	Under 3 (Set-up Charge: $200.00)		4
5-F-dU	90.00	110.00	350.00	Under 3 (Set-up Charge: $250.00)		4
2',3'-ddA	65.00	80.00	115.00	Under 3 (Set-up Charge: $150.00)		4
2',3'-ddC	65.00	80.00	115.00	Under 3 (Set-up Charge: $150.00)		4
2',3'-ddG	110.00	135.00	330.00	Under 3 (Set-up Charge: $250.00)		4
2',3'-ddT	65.00	80.00	115.00	Under 3 (Set-up Charge: $150.00)		4
AlexaFluor 488	180.00	200.00	350.00	1750.00		4
AlexaFluor 532	250.00	275.00	430.00	2150.00		4
AlexaFluor 546	250.00	275.00	430.00	2150.00		4
AlexaFluor 594	288.00	325.00	520.00	2600.00		4
AlexaFluor 647	180.00	200.00	350.00	1750.00		4
AlexaFluor 660	288.00	325.00	520.00	2600.00		4
AlexaFluor 750	288.00	325.00	520.00	2600.00		4
N6-methyl-2'-deoxyadenosine	120.00	150.00	220.00	Under 3 (Set-up Charge: $150.00)		4
PC (photo-cleavable) Amine Linker	120.00	150.00	220.00	Under 3 (Set-up Charge: $150.00)		4
PC (photo-cleavable) Biotin Linker	120.00	150.00	220.00	Under 3 (Set-up Charge: $250.00)		4
DNP (2,4-dinitrophenyl)-TEG	125.00	175.00	275.00	Under 3 (Set-up Charge: $150.00)		4
Cy3.5	180.00	250.00	380.00	1050.00		4
3'-dA	250.00	275.00	350.00			4
3'-dC	250.00	275.00	350.00			4
3'-dG	250.00	275.00	350.00			4
3'-dT	250.00	275.00	350.00			4
5-Nitroindole	125.00	175.00	250.00	450.00		4
2'-F-rA	65.00	80.00	115.00	Under 3 (Set-up Charge: $150.00)		4
2'-F-rC	65.00	80.00	115.00	Under 3 (Set-up Charge: $150.00)		4
2'-F-rG	65.00	80.00	115.00	Under 3 (Set-up Charge: $150.00)		4
2'-F-rU	65.00	80.00	115.00	Under 3 (Set-up Charge: $150.00)		4
Maleimide	50.00	65.00	95.00	350.00		4
2-Aminopurine	75.00	90.00	125.00	Under 3 (Set-up Charge: $150.00)		4
2,6-Diaminopurine	75.00	90.00	125.00	Under 3 (Set-up Charge: $150.00)		4
Dithiol	150.00	175.00	275.00	1500.00		4
BHQ2	180.00	220.00	330.00	900.00		4
EDTA-C2-dT	120.00	150.00	275.00	Under 3 (Set-up Charge: $250.00)		4
Thymidine Glycol	150.00	175.00	275.00	Under 3 (Set-up Charge: $150.00)		4
Zebularine	65.00	80.00	115.00	Under 3 (Set-up Charge: $150.00)		4
5' Methylene Blue	150.00	175.00	275.00	Under 3 (Set-up Charge: $250.00)		4
5' AMCA (amino-methyl-coumarin-acetate)	125.00	175.00	275.00	Under 3 (Set-up Charge: $150.00)		4
5' Deoxypurine (2’-DeoxyNebu larine)	75.00	90.00	125.00	Under 3 (Set-up Charge: $150.00)		4
5' PEG-2000	inquire {C}	inquire {C}	inquire {C}	inquire {C}		4
5' -BromoHexyl (Br)	150.00	175.00	275.00	1,500.00		4
5' Acridine	125.00	175.00	275.00	Under 3 (Set-up Charge: $150.00)		4
5' Acrylamide (acrydite)	90.00	110.00	350.00	1,250.00		4
5' -Yakima Yellow	250.00	275.00	350.00	Under 3 (Set-up Charge: $150.00)		4
O₆-Methyl 2'-dG	75.00	90.00	125.00	375.00	NA
O₄-Methyl-dT	75.00	90.00	125.00	375.00	NA
5' C3-Amine	50.00	60.00	80.00	240.00	NA
5' C12-Amine	75.00	90.00	125.00	375.00	NA
dT-Alkyne	225.00	250.00	350.00	1,750.00	NA
Rhodamine 6G	180.00	250.00	380.00	1,050.00	NA
Pyrene-Cap	225.00	250.00	350.00	1,750.00	NA
Epoch Eclips Quencher	225.00	250.00	350.00	1,750.00	NA
5'-Hexynyl	50.00	60.00	80.00	240.00	NA
Pyrene-dU	150.00	175.00	275.00	650.00
Perylene-dU	150.00	175.00	275.00	650.00
C8-Alkyne-dT	150.00	175.00	275.00	650.00
C8-Alkyne-dC	150.00	175.00	275.00	650.00
AminoOxy	125.00	150.00	220.00	550.00
Desthiobiotin TEG	150.00	175.00	275.00	750.00
N3-Methyl dC	150.00	175.00	275.00	650.00
N4-Ethyl dC	150.00	175.00	275.00	650.00
5'-OMe-dT	75.00	95.00	150.00	375.00
C6-Psoralen	225.00	250.00	350.00	1,750.00	NA
Marina blue	125.00	175.00	250.00	1,250.00	NA
DBCO TEG	180.00	220.00	330.00	900.00	NA
Azobenzene	125.00	175.00	250.00	1,250.00	NA

Internal Modification

Modification	Price/Modification ($)					Working Day
Modification	0.05 umole	0.2 umole	1 umole	10 umole	15 umole	Working Day
Internal Amino Modifier C6 dT	108.00	135.00	210.00	840.00	NA	4
Internal Biotin-dT	145.00	155.00	240.00	1200.00	NA	4
Fluorescein dT	145.00	175.00	240.00	1200.00	NA	4
C3 spacer	35.00	45.00	63.00	290.00	NA	4
C6 spacer	35.00	45.00	63.00	290.00	NA	4
C12 spacer	35.00	45.00	63.00	290.00	NA	4
18 atom spacer	45.00	50.00	80.00	320.00	NA	4
dS spacer	47.00	50.00	80.00	320.00	NA	4
Phosphorothioate (per insertion)	-	3.00	4.00	20.00	NA	4
5-Methyl dC	47.00	55.00	80.00	320.00	NA	4
Inosine	7.00	8.00	15.00	60.00	NA	4
Deoxy Uridine	7.00	7.50	11.00	55.00	NA	4
2'-O-Methyl	6.00	7.00	14.00	55.00	NA	4
5-Bromo dU	70.00	90.00	130.00	600.00	NA	4
8-Oxo-dA	145.00	175.00	240.00	1200.00	NA	4
8-Oxo-dG	145.00	175.00	240.00	1200.00	NA	4
Ferrocene-dT	145.00	155.00	240.00	1200.00	NA	4
5-hydroxymethyl-dC	145.00	175.00	240.00	1200.00	Under 3 (Set-up Charge: $350.00)	4
5-Hydroxy-dU	145.00	175.00	240.00	1200.00	Under 3 (Set-up Charge: $350.00)	4
5-hydroxymethyl-dU	145.00	175.00	240.00	1200.00	Under 3 (Set-up Charge: $350.00)	4
Ara-dC	80.00	100.00	310.00	Under 3 (Set-up Charge: $200.00)		4
5-F-dU	90.00	110.00	350.00	Under 3 (Set-up Charge: $250.00)		4
N6-methyl-2'-deoxyadenosine	120.00	150.00	220.00	Under 3 (Set-up Charge: $150.00)		4
PC (photo-cleavable)Linker	120.00	150.00	220.00	Under 3 (Set-up Charge: $250.00)		4
DNP (2,4-dinitrophenyl)-TEG	125.00	175.00	275.00	Under 3 (Set-up Charge: $150.00)		4
Cy3	160.00	200.00	350.00	1050.00
Cy5	160.00	200.00	350.00	1050.00
Cy3.5	180.00	250.00	380.00	1050.00
Cy5.5	180.00	250.00	380.00	1050.00
Puromycine	80.00	100.00	200.00	Under 3 (Set-up Charge: $150.00)
Yakima Yellow	120.00	150.00	220.00	Under 3 (Set-up Charge: $150.00)
3'-dA	250.00	275.00	350.00			4
3'-dC	250.00	275.00	350.00			4
3'-dG	250.00	275.00	350.00			4
3'-dT	250.00	275.00	350.00			4
5'-Nitroindole	125.00	175.00	250.00	450.00		4
2'-F-rA	65.00	80.00	115.00	Under 3 (Set-up Charge: $150.00)		4
2'-F-rC	65.00	80.00	115.00	Under 3 (Set-up Charge: $150.00)		4
2'-F-rG	65.00	80.00	115.00	Under 3 (Set-up Charge: $150.00)		4
2'-F-rU	65.00	80.00	115.00	Under 3 (Set-up Charge: $150.00)		4
2-Aminopurine	75.00	90.00	125.00	Under 3 (Set-up Charge: $150.00)		4
2,6-Diaminopurine	75.00	90.00	125.00	Under 3 (Set-up Charge: $150.00)		4
Dithiol	150.00	175.00	275.00	1500.00		4
EDTA-C2-dT	120.00	150.00	275.00	Under 3 (Set-up Charge: $250.00)		4
Thymidine Glycol	65.00	80.00	115.00	Under 3 (Set-up Charge: $150.00)		4
Zebularine	150.00	175.00	275.00	Under 3 (Set-up Charge: $150.00)		4
Biotin-TEG	50.00	65.00	95.00	380.00	NA	4
HEX-dT	55.00	66.00	138.00	600.00	Under 3 (Set-up Charge: $450.00)	4
Methylene Blue	150.00	175.00	275.00	Under 3 (Set-up Charge: $250.00)		4
Tamra-dT	220.00	250.00	350.00	1,750.00	NA	4
BHQ1-dT	250.00	275.00	350.00	1,750.00	NA	4
BHQ2-dT	250.00	275.00	350.00	1,750.00	NA	4
Dabcyl-dT	250.00	275.00	350.00	1,750.00	NA	4
Deoxypurine (2'-DeoxyNebu larine)	75.00	90.00	125.00	Under 3 (Set-up Charge: $250.00)		4
Azide	150.00	175.00	275.00	1,500.00	NA	4
Trebler Branching	220.00	250.00	350.00	1,750.00	NA	4
O₆-Methyl 2'-dG	75.00	90.00	125.00	375.00	NA
O₄-Methyl-dT	75.00	90.00	125.00	375.00	NA
dT-Alkyne	225.00	250.00	350.00	1,750.00	NA
Epoch Eclips Quencher	225.00	250.00	350.00	1,750.00	NA
Thiol-dT	225.00	250.00	350.00	1,750.00	NA
Cy3 dA	250.00	275.00	420.00	1,950.00	NA
Cy3 dC	250.00	275.00	420.00	1,950.00	NA
Cy3 dG	250.00	275.00	420.00	1,950.00	NA
Cy3 dT	225.00	250.00	350.00	1,750.00	NA
Cy5 dA	250.00	275.00	420.00	1,950.00	NA
Cy5 dC	250.00	275.00	420.00	1,950.00	NA
Cy5 dG	250.00	275.00	420.00	1,950.00	NA
Cy5 dT	225.00	250.00	350.00	1,750.00	NA
Pyrene-dU	150.00	175.00	275.00	650.00
Perylene-dU	150.00	175.00	275.00	650.00
C8-Alkyne-dT	150.00	175.00	275.00	650.00
C8-Alkyne-dC	150.00	175.00	275.00	650.00
Desthiobiotin TEG	150.00	175.00	275.00	750.00
N3-Methyl dC	150.00	175.00	275.00	650.00
N4-Ethyl dC	150.00	175.00	275.00	650.00
Azobenzene	125.00	175.00	250.00	1,250.00	NA
8-Br-dA	150.00	180.00	250.00	1,250.00	NA
8-Br-dG	150.00	180.00	250.00	1,250.00	NA
5-Br-dC	150.00	180.00	250.00	1,250.00	NA
6-thio-dG	225.00	250.00	350.00	1,750.00	NA
4-thio-dT	225.00	250.00	350.00	1,750.00	NA

For Standard oligos pricing, click here.

For orders larger than 96 oligos (High-Throughput) pricing, click here.

For Dual-labeled Probes pricing, click here.

Additional Service Price

Post-Handling	Tube Price ($)	Plate Price ($)
Concentration normalized-Standard	0.30	0.15 (per well)
Concentration normalized-Custom	0.40	0.20 (per well)
Bar-code Label	No Charge	No Charge
Dried	No Charge	No Charge
Aliquoting to daughter Plates	0.40	0.20 (per well)
Mixing primers	0.40	0.20 (per well)
Individual Tube plate-Labeled	-	0.40 (per well)
Custom plate	-	10.00
Double strand (Annealing service)	30.00/Pair	-
MALDI-TOF (QC)	No Charge	No Charge
MALDI-TOF (SNP or Genotyping)	-	2.00 (per well)
Shipping Charge	Shipping charge may apply	Shipping charge may apply
Hand mix service (MIX base Code)	100.00 (1~250base)	50.00 (1~250base)
Remainder in plate service	-	95.00 (96 well Plate), $ 150.00 (384 well Plate)
Circular ssDNA service	300.00/oligo	225,00 / oligo

Custom Analytical Service

Items	Tube Price ($)	Plate Price ($)	large scale
I-E HPLC	50.00	2.50 (per well)	50.00
RP HPLC	50.00	2.50 (per well)	50.00
Capillary electrophoresis	50.00	2.50 (per well)	50.00
PAGE analysis	15.00	1.00 (per well)	15.00
MALDI-TOF analysis, Spectrocheck	-	2.00 (per well)	-
MALDI-TOF analysis, other mass system	Free	Free	Free

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E-mail : oligos@bioneer.com.au